RGD Reference Report - Effects of caspase-9 and survivin gene polymorphisms in pancreatic cancer risk and tumor characteristics. - Rat Genome Database

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Effects of caspase-9 and survivin gene polymorphisms in pancreatic cancer risk and tumor characteristics.

Authors: Theodoropoulos, George E  Michalopoulos, Nikolaos V  Panoussopoulos, Sotirios-George  Taka, Styliani  Gazouli, Maria 
Citation: Theodoropoulos GE, etal., Pancreas. 2010 Oct;39(7):976-80. doi: 10.1097/MPA.0b013e3181d705d4.
RGD ID: 13451540
Pubmed: PMID:20357690   (View Abstract at PubMed)
DOI: DOI:10.1097/MPA.0b013e3181d705d4   (Journal Full-text)


OBJECTIVES: This case-control study was performed to evaluate the association between a specific caspase-9 polymorphism as well as the genetic polymorphism -31G/C located in the cycle-dependent elements/cell cycle homology regions repressor element of the human survivin promoter and the risk of pancreatic cancer.
METHODS: Eighty patients with pancreatic cancer and 160 healthy controls were investigated for genotype and allelic frequencies of caspase-9 1263A/G and survivin -31G/C polymorphisms by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism.
RESULTS: The G carrier group of patients and the G allele of caspase-9 1263A/G were overrepresented among the pancreatic cancer cases. With regard to tumor characteristics, a statistically significant association was detected between the survivin C carrier group of patients and the advanced T stage as well as the presence of lymph node metastasis.
CONCLUSIONS: The caspase-9 G allele confers increased susceptibility to pancreatic cancer development, and the survivin C carriage status may be related to aggressive features of this malignancy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic cancer susceptibilityIAGP 13451540DNA:snp:promoter:g.-1263A>G (human)RGD 
pancreatic cancer susceptibilityISOCASP9 (Homo sapiens)13451540; 13451540DNA:snp:promoter:g.-1263A>G (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal pancreas morphology susceptibilityIAGP 13451540DNA:snp:promoter:g.-1263A>GRGD 
Objects Annotated

Genes (Rattus norvegicus)
Casp9  (caspase 9)

Genes (Mus musculus)
Casp9  (caspase 9)

Genes (Homo sapiens)
CASP9  (caspase 9)


Additional Information