RGD Reference Report - GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3ß in rat kidney. - Rat Genome Database

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GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3ß in rat kidney.

Authors: Liu, Biying  Zhang, Haili  Tan, Xiao  Yang, Daqian  Lv, Zhanjun  Jiang, Huijie  Lu, Jingjing  Baiyun, Ruiqi  Zhang, Zhigang 
Citation: Liu B, etal., Oncotarget. 2017 Jun 27;8(26):42226-42237. doi: 10.18632/oncotarget.15033.
RGD ID: 13440092
Pubmed: PMID:28178683   (View Abstract at PubMed)
PMCID: PMC5522062   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.15033   (Journal Full-text)

Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, the present study investigated whether GSPE reduced Pb-induced nephrotoxicity as well as the protective mechanism of GSPE in a well-established 35-day Pb induced nephrotoxicity rat model. The results showed that GSPE normalized Pb-induced oxidative stress, histological damage, inflammatory, apoptosis, and changes of miR153 and glycogen synthase kinase 3ß (GSK-3ß) levels in rat kidney. Moreover, GSPE enhanced the induction of phase II detoxifying enzymes (heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1) by increasing nuclear factor-erythroid-2-related factor 2 (Nrf2) expression. This study identifies for the first time that Pb-induced oxidative stress in rat kidney is attenuated by GSPE treatment via activating Nrf2 signaling pathway and suppressing miR153 and GSK-3ß. Nrf2 signaling provides a new therapeutic target for renal injury induced by Pb, and GSPE could be a potential natural agent to protect against Pb-induced nephrotoxicity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lead Poisoning treatmentISONqo1 (Rattus norvegicus)13440092; 13440092 RGD 
Lead Poisoning treatmentIEP 13440092 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nqo1  (NAD(P)H quinone dehydrogenase 1)

Genes (Mus musculus)
Nqo1  (NAD(P)H dehydrogenase, quinone 1)

Genes (Homo sapiens)
NQO1  (NAD(P)H quinone dehydrogenase 1)


Additional Information