RGD Reference Report - High expression of Parkin predicts easier recurrence of patients with adjuvant transarterial chemoembolization. - Rat Genome Database

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High expression of Parkin predicts easier recurrence of patients with adjuvant transarterial chemoembolization.

Authors: Zhang, Changlie  Song, Zhihong  Yu, Guangji 
Citation: Zhang C, etal., Biomark Med. 2017 Sep 1. doi: 10.2217/bmm-2017-0129.
RGD ID: 13432206
Pubmed: PMID:28862485   (View Abstract at PubMed)
DOI: DOI:10.2217/bmm-2017-0129   (Journal Full-text)


AIM: To investigate the clinical significance of E3 ubiquitin ligase Parkin in patients with adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma.
METHODS: Parkin expression of hepatocellular carcinomas was detected and its correlation with clinicopathological factors was analyzed with ¿(2) test. The significance of Parkin in prognosis and recurrence was analyzed with log-rank test and the Cox-regression model.
RESULTS: High expression of Parkin could result in lower recurrence-free survival rate instead of overall survival rate. Larger tumor size, positive tumor recurrence, advanced T, N, M and TNM stage were significantly associated with poorer prognosis. Larger tumor size, advanced T and TNM stage could lead to higher recurrence.
CONCLUSION: High Parkin expression could predict easier recurrence to patients with adjuvant transarterial chemoembolization.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma severityISOPrkn (Mus musculus)13432206; 13432206protein:decreased expression:liver (human)RGD 
hepatocellular carcinoma severityIEP 13432206protein:decreased expression:liver (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prkn  (parkin RBR E3 ubiquitin protein ligase)

Genes (Mus musculus)
Prkn  (parkin RBR E3 ubiquitin protein ligase)

Genes (Homo sapiens)
PRKN  (parkin RBR E3 ubiquitin protein ligase)


Additional Information