RGD Reference Report - Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? - Rat Genome Database

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Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?

Authors: Baker, JE  Konorev, EA  Gross, GJ  Chilian, WM  Jacob, HJ 
Citation: Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
RGD ID: 1342469
Pubmed: PMID:10749737   (View Abstract at PubMed)

There is a need to develop new and more consistent animal models of cardioprotection. Traditionally, outbred dogs, rabbits, and rats have been studied. We determined resistance to ischemia in isolated hearts from inbred strains of rats. Hearts from inbred rats: SS/Mcw (Dahl S, Dahl salt-sensitive), DA/Hsd (Dark Agouti), LEW/Hsd (Lewis), and BN/SsN/Mcw (Brown Norway); and from an outbred rat: Hsd:WIST (Wistar) were subjected to 27 min of global, no-flow ischemia, followed by 3 h of reperfusion. Infarct size in the Brown Norway rat was 2.5 times less than that observed in the Dahl S rat, with the Dark Agouti, Lewis, and Wistar rats intermediate in response. Hearts from Brown Norway rats were also most resistant to ischemia in terms of postischemic enzyme leakage and contractile and vascular function compared with other strains. The average polymorphism rate between strains revealed that such strains were genetically diverse. This study demonstrates strain differences in resistance to myocardial ischemia, suggesting these rats could be used to study a genetic and/or environmental basis for these differences and to provide new animal models for the physiological study of cardioprotection.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased coronary flow rate inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469; 1342469; 1342469; 1342469 RGD 
decreased heart rate inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469 RGD 
decreased lactate dehydrogenase level inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469; 1342469; 1342469compared to SS/JrHsdMcwiRGD 
decreased left ventricle developed pressure inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469; 1342469; 1342469; 1342469; 1342469 RGD 
decreased myocardial infarct size  IAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469compared to SS/JrHsdMcwiRGD 
increased coronary flow rate inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469compared to SS/JrHsdMcwiRGD 
increased coronary flow rate inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469compared to SS/JrHsdMcwiRGD 
increased left ventricle developed pressure inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469compared to SS/JrHsdMcwiRGD 
increased left ventricle developed pressure inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469; 1342469; 1342469compared to SS/JrHsdMcwiRGD 
increased time of peak ischemic contracture inducedIAGPcontrolled ex vivo organ condition and controlled air oxygen content1342469compared to SS/JrHsdMcwiRGD 
Objects Annotated

Strains
BN/NHsdMcwi  (NA)
DA/OlaHsd  (NA)
Hsd:WI  (Wistar)
LEW/SsNHsd  (NA)
SS/JrHsdMcwi  (NA)

Objects referenced in this article
Strain LEW Lewis Rattus norvegicus
Strain LEW/NHsd null Rattus norvegicus

Additional Information