RGD Reference Report - Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. - Rat Genome Database

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Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.

Authors: Astrom, AK  Jin, D  Imamura, T  Roijer, E  Rosenzweig, B  Miyazono, K  Ten Dijke, P  Stenman, G 
Citation: Astrom AK, etal., Mamm Genome 1999 Mar;10(3):299-302.
RGD ID: 1334467
Pubmed: PMID:10051328   (View Abstract at PubMed)

Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily that play a pivotal role in bone formation during embryogenesis and fracture repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinase complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR-II). BMPR-IA and IB are closely related receptors, with sequence differences conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes. Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23.

Objects referenced in this article
Gene Bmpr1b bone morphogenetic protein receptor type 1B Rattus norvegicus

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