RGD Reference Report - Glycosylation regulates Notch signalling. - Rat Genome Database

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Glycosylation regulates Notch signalling.

Authors: Haines, N  Irvine, KD 
Citation: Haines N and Irvine KD, Nat Rev Mol Cell Biol 2003 Oct;4(10):786-97.
RGD ID: 1334453
Pubmed: PMID:14570055   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm1228   (Journal Full-text)

Intracellular post-translational modifications such as phosphorylation and ubiquitylation have been well studied for their roles in regulating diverse signalling pathways, but we are only just beginning to understand how differential glycosylation is used to regulate intercellular signalling. Recent studies make clear that extracellular post-translational modifications, in the form of glycosylation, are essential for the Notch signalling pathway, and that differences in the extent of glycosylation are a significant mechanism by which this pathway is regulated.

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Genes (Rattus norvegicus)
Pofut1  (protein O-fucosyltransferase 1)


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