RGD Reference Report - Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis. - Rat Genome Database

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Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis.

Authors: Lamb, Rebecca  Thomson, Wendy  British Society of Paediatric and Adolescent Rheumatology,   Ogilvie, Emma M  Donn, Rachelle 
Citation: Lamb R, etal., Arthritis Rheum. 2007 Apr;56(4):1286-91.
RGD ID: 13208931
Pubmed: PMID:17393463   (View Abstract at PubMed)
DOI: DOI:10.1002/art.22444   (Journal Full-text)


OBJECTIVE: To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA).
METHODS: Nine polymorphisms across the SLC26A2 gene locus were investigated using MassArray genotyping in 826 UK Caucasian JIA cases and 617 ethnically matched healthy controls.
RESULTS: Significant associations between multiple single-nucleotide polymorphisms (SNPs) across SLC26A2 and systemic-onset JIA were found. In each case, homozygosity for the minor allele conferred the increased risk of disease susceptibility: rs1541915 (odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.7, P=0.0003), rs245056 (OR 2.8, 95% CI 1.7-4.6, P=0.00002), rs245055 (OR 2.5, 95% CI 1.2-5.0, P=0.004), rs245051 (OR 2.3, 95% CI 1.4-3.7, P=0.0005), rs245076 (OR 2.7, 95% CI 1.3-5.4, P=0.0015), and rs8073 (OR 2.3, 95% CI 0.9-5.6, P=0.04).
CONCLUSION: These findings show the value of using monogenic disease loci as candidates for investigation in JIA. We identified a subgroup-specific association between SNPs within the SLC26A2 gene and systemic-onset JIA. Our findings also highlight systemic-onset JIA as being a distinctly different disease from that in the other JIA subgroups.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
juvenile rheumatoid arthritis susceptibilityIAGP 13208931DNA:SNPs: :RGD 
juvenile rheumatoid arthritis susceptibilityISOSLC26A2 (Homo sapiens)13208931; 13208931DNA:SNPs: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc26a2  (solute carrier family 26 member 2)

Genes (Mus musculus)
Slc26a2  (solute carrier family 26 (sulfate transporter), member 2)

Genes (Homo sapiens)
SLC26A2  (solute carrier family 26 member 2)


Additional Information