RGD Reference Report - Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium. - Rat Genome Database

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Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium.

Authors: Li, Rui-Fang  Cao, Shan-Shan  Fang, Wei-Jin  Song, Ying  Luo, Xue-Ting  Wang, Hong-Yun  Wang, Jian-Gang 
Citation: Li RF, etal., Pharmacology. 2017;99(1-2):27-39. doi: 10.1159/000449467. Epub 2016 Sep 27.
RGD ID: 13208809
Pubmed: PMID:27673327   (View Abstract at PubMed)
DOI: DOI:10.1159/000449467   (Journal Full-text)

Recent studies indicate that histone deacetylases (HDACs) activity is associated with the development and progression of cardiac hypertrophy. In this study, we investigated the effects of a HDACs inhibitor, valproic acid sodium (VPA), on cardiac remodeling and the differential expression of HDACs in left ventricles (LVs) of renovascular hypertensive rats. Renovascular hypertension was induced in rats by the two-kidney two-clip (2K2C) method. Cardiac remodeling, heart function and the differential expression of HDACs were examined at different weeks after 2K2C operation. The effects of VPA on cardiac remodeling, the expressions of HDACs, transforming growth factor-beta 1 (TGF-ß1) and connective tissue growth factor (CTGF) in LV were investigated. The expressions of atrial natriuretic factor, ß-myosin heavy chain, HDAC2 and HDAC8 increased in LV of 2K2C rats at 4, 8, 12 weeks after operation. Cardiac dysfunction, cardiac hypertrophy and fibrosis were markedly attenuated by VPA treatment in 2K2C rats. Further studies revealed that VPA inhibited the expressions of HDAC2, HDAC8, TGF-ß1 and CTGF in LV of 2K2C rats. In summary, these data indicate that HDAC2 and HDAC8 play a key role in cardiac remodeling in renovascular hypertensive rats and that VPA attenuates hypertension and cardiac remodeling. The effect of VPA is possibly exerted via decreasing HDAC2, HDAC8, TGF-ß1 and CTGF expressions in LV of 2K2C rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renovascular hypertension treatmentISOHdac8 (Rattus norvegicus)13208809; 13208809 RGD 
renovascular hypertension treatmentIEP 13208809 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hdac8  (histone deacetylase 8)

Genes (Mus musculus)
Hdac8  (histone deacetylase 8)

Genes (Homo sapiens)
HDAC8  (histone deacetylase 8)


Additional Information