RGD Reference Report - A Drosophila model of Parkinson's disease. - Rat Genome Database

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A Drosophila model of Parkinson's disease.

Authors: Feany, MB  Bender, WW 
Citation: Feany MB and Bender WW, Nature 2000 Mar 23;404(6776):394-8.
RGD ID: 1302583
Pubmed: PMID:10746727   (View Abstract at PubMed)
DOI: DOI:10.1038/35006074   (Journal Full-text)

Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.

Objects referenced in this article
Gene SNCA synuclein alpha Homo sapiens
Gene Snca synuclein alpha Rattus norvegicus

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