RGD Reference Report - Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver. - Rat Genome Database

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Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.

Authors: Sidorova, YA  Grishanova, AY 
Citation: Sidorova YA and Grishanova AY, Bull Exp Biol Med 2004 Mar;137(3):231-4.
RGD ID: 1300400
Pubmed: PMID:15232626   (View Abstract at PubMed)

We studied the effect of synthetic vitamin K analogue menadione on enzymes of xenobiotic metabolism in rat liver (total content of cytochrome P450 and catalytic activities of CYP1A1/2, CYP2B1, CYP2C, NADPH-cytochrome P450 reductase, and glutathione S-transferase). Menadione induced phase I and II enzymes for metabolism of xenobiotics, drugs, and procarcinogens. The effect of menadione depended on its dose and duration of treatment.


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