RGD Reference Report - A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. - Rat Genome Database

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A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors.

Authors: Andersson, P  McGuire, J  Rubio, C  Gradin, K  Whitelaw, ML  Pettersson, S  Hanberg, A  Poellinger, L 
Citation: Andersson P, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):9990-5. Epub 2002 Jul 9.
RGD ID: 1300278
Pubmed: PMID:12107286   (View Abstract at PubMed)
PMCID: PMC126612   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.152706299   (Journal Full-text)

The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation.

Objects referenced in this article
Gene AHR aryl hydrocarbon receptor Homo sapiens
Gene Ahr aryl hydrocarbon receptor Rattus norvegicus

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