RGD Reference Report - An essential role for ectodomain shedding in mammalian development. - Rat Genome Database

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An essential role for ectodomain shedding in mammalian development.

Authors: Peschon, JJ  Slack, JL  Reddy, P  Stocking, KL  Sunnarborg, SW  Lee, DC  Russell, WE  Castner, BJ  Johnson, RS  Fitzner, JN  Boyce, RW  Nelson, N  Kozlosky, CJ  Wolfson, MF  Rauch, CT  Cerretti, DP  Paxton, RJ  March, CJ  Black, RA 
Citation: Peschon JJ, etal., Science 1998 Nov 13;282(5392):1281-4.
RGD ID: 1300253
Pubmed: PMID:9812885   (View Abstract at PubMed)

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.

Objects referenced in this article
Gene ADAM17 ADAM metallopeptidase domain 17 Homo sapiens
Gene Adam17 a disintegrin and metallopeptidase domain 17 Mus musculus
Gene Adam17 ADAM metallopeptidase domain 17 Rattus norvegicus

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