RGD Reference Report - Determination of the mRNA sequence of cathepsin Y, a cysteine endopeptidase from rat spleen, 1 and confirmation of its ubiquitous expression. - Rat Genome Database

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Determination of the mRNA sequence of cathepsin Y, a cysteine endopeptidase from rat spleen, 1 and confirmation of its ubiquitous expression.

Authors: Nakazono, E  Kamata, Y  Yamafuji, K 
Citation: Nakazono E, etal., Biol Chem 2002 Dec;383(12):1971-5.
RGD ID: 1299468
Pubmed: PMID:12553736   (View Abstract at PubMed)
DOI: DOI:10.1515/BC.2002.223   (Journal Full-text)

A cysteine endopeptidase from rat spleen was purified, characterized and its gene cloned. This enzyme was originally recognized by its action of producing kinin-potentiating peptide from a plasma protein. We named it cathepsin Y due to its localization, acidic pH optimum and the presence of the same set of active site amino acids as in other thiol cathepsins. Here we show the total sequence of the mRNA obtained by means of TaKaRa 5' Full RACE Core Set and complete the previously reported sequence. This completion of the mRNA sequence resulted in the omission of the strangely attached C-terminal peptide from cathepsin Y.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cysteine-type endopeptidase activity  TAS 1299468 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctsz  (cathepsin Z)


Additional Information