RGD Reference Report - CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. - Rat Genome Database

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CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family.

Authors: Kang, JS  Gao, M  Feinleib, JL  Cotter, PD  Guadagno, SN  Krauss, RS 
Citation: Kang JS, etal., J Cell Biol 1997 Jul 14;138(1):203-13.
RGD ID: 1299440
Pubmed: PMID:9214393   (View Abstract at PubMed)
PMCID: PMC2139939   (View Article at PubMed Central)

Cell adhesion molecules of the Ig superfamily are implicated in a wide variety of biological processes, including cell migration, axon guidance and fasciculation, and growth control and tumorigenesis. Expression of these proteins can be highly dynamic and cell type specific, but little is known of the signals that regulate such specificity. Reported here is the molecular cloning and characterization of rat CDO, a novel cell surface glycoprotein of the Ig superfamily that contains five Ig-like repeats, followed by three fibronectin type III-like repeats in its extracellular region, and a 256-amino acid intracellular region that does not resemble other known proteins. In rat embryo fibroblasts, cdo mRNA expression is maximal in confluent, quiescent cells. It is rapidly and transiently down-regulated by serum stimulation of such cells, and is constitutively down-regulated in oncogene-transformed derivatives of these cells. CDO protein levels are also dramatically regulated by cell-substratum adhesion, via a mechanism that is independent of cdo mRNA expression. The amount of CDO produced at the surface of a cell may therefore be governed by a complex balance of signals, including mitogenic stimuli that regulate cdo mRNA levels, and substratum-derived signals that regulate CDO protein production. cdo mRNA is expressed at low levels in most adult rat tissues. A closely related human gene maps to chromosome 11q23-24, a region that displays frequent loss of heterozygosity in human lung, breast, and ovarian tumors. Taken together, these data suggest that loss of CDO function could play a role in oncogenesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell adhesion  IMP 1299440 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell surface located_inIDA 1299440PMID:9214393MGI 
cell surface  IDA 1299440 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdon  (cell adhesion associated, oncogene regulated)

Objects referenced in this article
Gene CDON cell adhesion associated, oncogene regulated Homo sapiens
Gene Cdon cell adhesion molecule-related/down-regulated by oncogenes Mus musculus

Additional Information