RGD Reference Report - Delta-aminolevulinate dehydratase activity in mice with hereditary anemia. - Rat Genome Database

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Delta-aminolevulinate dehydratase activity in mice with hereditary anemia.

Authors: Margolis, F L  Russell, E S 
Citation: Margolis FL and Russell ES, Science. 1965 Oct 22;150(3695):496-7.
RGD ID: 12904678
Pubmed: PMID:5891055   (View Abstract at PubMed)

Homozygous (f/f) but not heterozygous (f/+) mice of the highly congenic strain, FL/ Re, manifest a severe transitory siderocytic fetal anemia. Adults of both f/f and f/+ genotype manifest decreased hepatic, splenic, and renal levels of triangle up-amino-levulinate dehydratase (ALD) activity compared to homozygous (+/+) mice of the same strain. The degree of augmentation in splenic ALD activity following phenylhydrazine administration is high in +/+, intermediate in f/+, and low in f/f mice. These findings suggest that perhaps a deficiency in the fetal level of ALD may be responsible for the transitory fetal anemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sideroblastic anemia  ISOAlad (Mus musculus)12904678; 12904678protein:decreased activity:kidney more ...RGD 
sideroblastic anemia  IDA 12904678protein:decreased activity:kidney more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alad  (aminolevulinate dehydratase)

Genes (Mus musculus)
Alad  (aminolevulinate, delta-, dehydratase)

Genes (Homo sapiens)
ALAD  (aminolevulinate dehydratase)


Additional Information