RGD Reference Report - Evaluation of the maternal and umbilical vein serum sFas/sFasL system in pregnancies complicated by preeclampsia with intrauterine growth retardation. - Rat Genome Database

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Evaluation of the maternal and umbilical vein serum sFas/sFasL system in pregnancies complicated by preeclampsia with intrauterine growth retardation.

Authors: Laskowska, Marzena  Laskowska, Katarzyna  Leszczynska-Gorzelak, Bozena  Oleszczuk, Jan 
Citation: Laskowska M, etal., Eur J Obstet Gynecol Reprod Biol. 2006 Jun 1;126(2):155-9. Epub 2005 Sep 19.
RGD ID: 12904025
Pubmed: PMID:16169656   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejogrb.2005.08.015   (Journal Full-text)


OBJECTIVE: The aim of this study was to determine the maternal and umbilical vein soluble Fas and its ligand (sFasL) serum levels in pregnancies complicated by preeclampsia with intrauterine growth retardation (IUGR).
PATIENTS AND METHODS: The study was carried out on 11 preeclamptic delivering patients in the third trimester of pregnancy with severe preeclampsia complicated by intrauterine growth retardation. The control group consisted of 12 healthy normotensive delivering patients with singleton uncomplicated pregnancies, without any renal, heart and vascular diseases and with normal laboratory tests. Maternal and umbilical serum soluble Fas and FasL concentrations were estimated using a sandwich ELISA assay.
RESULTS AND CONCLUSIONS: Increased maternal and umbilical vein serum sFas and increased umbilical vein serum sFasL levels were found in the study group in comparison with the control group. In our study in both groups of patient higher maternal sFas values were observed in comparison with the umbilical cord blood. Further studies are necessary to evaluate the role of Fas/FasL pathway in pregnancies complicated by preeclampsia and intrauterine growth retardation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fetal Growth Retardation  IEP 12904025; 12904025associated with protein:increased expression:serum:RGD 
Fetal Growth Retardation  ISOFAS (Homo sapiens)12904025; 12904025associated with protein:increased expression:serum:RGD 
Fetal Growth Retardation  ISOFASLG (Homo sapiens)12904025; 12904025associated with protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)
Faslg  (Fas ligand)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)
Fasl  (Fas ligand)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)
FASLG  (Fas ligand)


Additional Information