RGD Reference Report - Soluble Fas and Fas-ligand levels in mid-trimester amniotic fluid and their associations with severe small for gestational age fetuses: a prospective observational study.

General

Soluble Fas and Fas-ligand levels in mid-trimester amniotic fluid and their associations with severe small for gestational age fetuses: a prospective observational study.
Authors:	Vrachnis, N Dalainas, I Papoutsis, D Samoli, E Rizos, D Iliodromiti, Z Siristatidis, C Tsikouras, P Creatsas, G Botsis, D
Citation:	Vrachnis N, etal., J Reprod Immunol. 2013 Jun;98(1-2):39-44. doi: 10.1016/j.jri.2013.02.003. Epub 2013 Apr 10.
RGD ID:	12903972
Pubmed:	PMID:23582102 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.jri.2013.02.003 (Journal Full-text)
We aimed to determine the second-trimester amniotic fluid (AF) levels of soluble Fas (sFas) and Fas-ligand (FasL) and investigate their association with fetal growth. Therefore, sFas and FasL levels were measured by enzyme immunoassay in the AF of 21 small for gestational age (SGA), 13 large for gestational age (LGA), and 44 appropriate for gestational age (AGA) fetuses of pregnant women who underwent amniocentesis at between 15 and 22 weeks gestation. Our study results showed that sFas and FasL levels were detectable in AF. sFAS median (25th-75th centile) levels were 3.8 (2.8-4.6) ng/ml in SGA, 3.6 (3.1-4.5) ng/ml in AGA, and 4.0 (3.1-4.4) ng/ml in LGA. FasL median (25th-75th centile) levels were 26.0 (20.3-32.7) pg/ml in SGA, 22.7 (18.4-28.5) pg/ml in AGA, and 21.5 (15.8-30.9) pg/ml in LGA. The differences were not statistically significant. Nevertheless, statistically significant differentiation of FasL levels existed when SGA fetuses in the extremes of distribution (<=5th, <=2.5th centile) were considered. This is the first study presenting sFas and FasL concentrations in early second-trimester amniotic fluid in AGA, SGA, and LGA fetuses. We found indications that severe and very severe SGA fetuses (<=5th and <=2.5th centile) have high levels of FasL in the amniotic fluid. This finding probably reflects the increased rate of apoptosis that is assumed to exist in cases of extreme growth restriction.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fetal Growth Retardation	severity	IEP		12903972	protein:increased expression:amniotic fluid:	RGD
Fetal Growth Retardation	severity	ISO	FASLG (Homo sapiens)	12903972; 12903972	protein:increased expression:amniotic fluid:	RGD

Objects Annotated

Genes (Rattus norvegicus)

Faslg (Fas ligand)

Genes (Mus musculus)

Fasl (Fas ligand)

Genes (Homo sapiens)

FASLG (Fas ligand)

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Soluble Fas and Fas-ligand levels in mid-trimester amniotic fluid and their associations with severe small for gestational age fetuses: a prospective observational study.