RGD Reference Report - Upregulation of Fas/Fas ligand in inclusion body myositis. - Rat Genome Database

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Upregulation of Fas/Fas ligand in inclusion body myositis.

Authors: Fyhr, I M  Oldfors, A 
Citation: Fyhr IM and Oldfors A, Ann Neurol. 1998 Jan;43(1):127-30.
RGD ID: 12903959
Pubmed: PMID:9450780   (View Abstract at PubMed)
DOI: DOI:10.1002/ana.410430123   (Journal Full-text)

In inclusion body myositis, T cells invade and destroy nonnecrotic muscle fibers. The mechanism by which T cells damage muscle fibers in inflammatory myopathies is not known. In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis. Reverse transcription polymerase chain reaction showed upregulation of both Fas and Fas ligand in all inclusion body myositis patients. Immunohistochemical investigation showed expression of Fas ligand in many of the muscle infiltrating mononuclear cells. Fas was expressed both in mononuclear cells and on the surface of muscle fibers in inclusion body myositis patients and in patients with polymyositis but not in patients with Duchenne muscular dystrophy or denervation. The results indicate that the Fas/Fas ligand system may be of importance for the inflammatory reaction and T-cell-mediated muscle cell injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
inclusion body myositis  IEP 12903959mRNA and protein:increased expression:muscleRGD 
inclusion body myositis  ISOFAS (Homo sapiens)12903959; 12903959mRNA and protein:increased expression:muscleRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)


Additional Information