RGD Reference Report - Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat. - Rat Genome Database

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Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat.

Authors: Kohara, K  Mikami, H  Okuda, N  Higaki, J  Ogihara, T 
Citation: Kohara K, etal., Hypertension. 1993 Jun;21(6 Pt 2):975-9.
RGD ID: 12880006
Pubmed: PMID:8505110   (View Abstract at PubMed)

The pathophysiological role of angiotensin II in the development of renal sclerosis was investigated in 5/6-nephrectomized, 12-week-old male spontaneously hypertensive rats. After 1 week of a control period, nephrectomized rats received one of the following treatments for 4 weeks: the selective nonpeptide angiotensin II type 1 receptor antagonist TCV-116 (1 mg/kg per day), the angiotensin converting enzyme inhibitor delapril (30 mg/kg per day), hydralazine (15 mg/kg per day), or vehicle. Urinary protein and albumin excretions and systolic blood pressure were determined every week. Rats with reduced renal mass treated with vehicle had a poor survival rate (30%). Although TCV-116, delapril, and hydralazine treatment significantly improved the survival rate for 4 weeks, hydralazine failed to improve proteinuria and albuminuria as well as the decline in renal function compared with delapril or TCV-116. Histological examination revealed that both TCV-116 and delapril protected glomeruli from sclerosis, whereas hydralazine did not improve histological findings (5%, 7%, and 30% of glomeruli were affected, respectively). These results indicate that angiotensin II plays a dominant role through its type 1 receptor in the pathogenesis of renal deterioration by hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
focal segmental glomerulosclerosis 1 treatmentISOAce (Rattus norvegicus)12880006; 12880006 RGD 
focal segmental glomerulosclerosis 1 treatmentIMP 12880006 RGD 


Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information