RGD Reference Report - An experimental model of encapsulating peritoneal sclerosis. - Rat Genome Database

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An experimental model of encapsulating peritoneal sclerosis.

Authors: Sawada, Tokihiko  Ishii, Yasuo  Nakajima, Ichiro  Fuchinoue, Shohei  Kubota, Keiichi  Teraoka, Satoshi 
Citation: Sawada T, etal., Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50.
RGD ID: 12879821
Pubmed: PMID:19270231   (View Abstract at PubMed)

In Japan, only about 3% of all patients with end-stage renal disease are maintained by continuous ambulatory peritoneal dialysis (CAPD). Although the reasons for the low proportion of patients receiving CAPD are multifactorial, encapsulating peritoneal sclerosis (EPS), a fatal complication of CAPD, is a major factor. In 1995 we developed a rat model of EPS, and in 2001 also developed an EPS model in mice. These rodent EPS models are reliable, reproducible, and inexpensive and have been used by other investigators. The renin-angiotensin system negatively regulates the transforming growth factor-beta signaling pathway, which plays a major role in tissue fibrosis. To investigate the anti-EPS effect of renin-angiotensin system inhibition, an angiotensin-converting enzyme inhibitor, quinapril, was administered to an EPS model in mice. Quinapril was found to inhibit EPS, both macro- and microscopically, in a dose-dependent manner. We report our experience of developing the experimental in vivo EPS model, and the inhibitory effect of this angiotensin-converting enzyme inhibitor on EPS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Peritoneal Fibrosis treatmentISOAce (Mus musculus)12879821; 12879821 RGD 
Peritoneal Fibrosis treatmentIMP 12879821 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information