RGD Reference Report - Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine. - Rat Genome Database

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Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine.

Authors: Cruz, C I  Ruiz-Torres, P  del Moral, R G  Rodríguez-Puyol, M  Rodríguez-Puyol, D 
Citation: Cruz CI, etal., Am J Physiol Renal Physiol. 2000 Jan;278(1):F122-9.
RGD ID: 12879403
Pubmed: PMID:10644663   (View Abstract at PubMed)

Our previous studies demonstrated an increased reactive oxygen species (ROS) production, as well as transforming growth factor-beta1 (TGF-beta1) expression in the rat kidney with aging. In the present study, we examined the effect of aging on extracellular matrix (ECM) accumulation and the effects of treatment with angiotensin-converting enzyme inhibitors (captopril and lisinopril) and taurine, an antioxidant amino acid. Age-related increases in types I and IV collagen and fibronectin mRNA expression were found at 24 and 30 mo of age. In contrast, type III collagen only increased in 30-mo-old rats. Captopril-, lisinopril-, and taurine-treated animals showed a statistically significant decrease in ECM protein expression at both ages. Moreover, treatment with taurine reduced the TGF-beta1 mRNA levels in 24- and 30-mo-old rats by 40%. Taurine also completely blocked increases in type I and type IV collagen expression in mesangial cells in response to TGF-beta1. Our results demonstrate a protective role from both converting enzyme inhibitors and taurine in the age-related progressive renal sclerosis. In addition, taking into account that taurine is considered as an antioxidant amino acid, present data suggest a role for ROS in age-related progressive renal fibrosis, perhaps through interactions with the TGF-beta1 pathway.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal fibrosis treatmentISOAce (Rattus norvegicus)12879403; 12879403 RGD 
renal fibrosis treatmentIMP 12879403 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information