RGD Reference Report - A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction. - Rat Genome Database

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A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction.

Authors: Delpisheh, Ali  Brabin, Loretta  Topping, Joanne  Reyad, Manal  Tang, Ai-Wei  Brabin, Bernard J 
Citation: Delpisheh A, etal., Eur J Obstet Gynecol Reprod Biol. 2009 Mar;143(1):38-42. doi: 10.1016/j.ejogrb.2008.11.006. Epub 2009 Jan 14.
RGD ID: 12792219
Pubmed: PMID:19147266   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejogrb.2008.11.006   (Journal Full-text)


OBJECTIVES: To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
STUDY DESIGN: A case-control study was conducted to investigate if the association of pregnancy smoking and birth outcome was modulated by maternal gene polymorphisms. A total of 90 mothers with an IUGR baby (cases) and 180 mothers without IUGR (controls) were enrolled.
RESULTS: Almost half of smokers who carried a CYP1A1 variant (51.3%), GSTT1 null (43.6%), or GSTM1 null genotypes (64.1%) delivered a baby with IUGR. Smokers with the variant CYP1A1 "aa" genotype had babies with lower mean birthweight than non-smokers with the same genotype (p=0.004). An interaction test showed increased prevalence of IUGR in smokers with the CYP1A1 (Aa/aa) variant (adjusted OR, 1.9; 95% CI, 1.4-5.5, p=0.01), or with the GSTT1 null (AOR, 1.5; 1.1-3.1, p=0.001), or GSTM1 null genotypes (AOR, 1.5; 1.2-3.7, p=0.001).
CONCLUSIONS: Risk of fetal growth restriction in mothers who smoked during pregnancy was modulated by maternal metabolic gene polymorphisms. The genetic control of the conversion of toxic metabolites of tobacco smoke to less damaging substances is important for maternal and fetal health.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Fetal Growth Retardation  IAGP 12792219; 12792219DNA:deletion:: (human)RGD 
Fetal Growth Retardation  ISOGSTM1 (Homo sapiens)12792219; 12792219DNA:deletion:: (human)RGD 
Fetal Growth Retardation  ISOGSTT1 (Homo sapiens)12792219; 12792219DNA:deletion:: (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Small for gestational age  IAGP 12792219DNA:deletion::RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)
GSTT1  (glutathione S-transferase theta 1)


Additional Information