RGD Reference Report - Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase. - Rat Genome Database

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Cardiolipin is the membrane receptor for mitochondrial creatine phosphokinase.

Authors: Muller, M  Moser, R  Cheneval, D  Carafoli, E 
Citation: Muller M, etal., J Biol Chem. 1985 Mar 25;260(6):3839-43.
RGD ID: 11565108
Pubmed: PMID:3972849   (View Abstract at PubMed)

Treatment of rat heart mitochondria with phosphate or mersalyl releases a number of proteins, including the mitochondrial creatine kinase (mt-CK). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the released proteins showed that phosphate is more selective than mersalyl in releasing mt-CK. The rebinding of mt-CK to mitochondria was selectively inhibited by adriamycin, which complexes membrane-bound cardiolipin. mt-CK activity and binding experiments have shown that intact mitochondria are able to bind approximately twice the amount of mt-CK they originally contain. Liver mitochondria bound heart mitochondria mt-CK to the same extent as creatine kinase-depleted heart mitochondria. mt-CK was bound by liposomes but only if they contained cardiolipin. The binding of mt-CK to cardiolipin-containing liposomes was inhibited by adriamycin. Phosphatidylcholine liposomes reconstituted with the purified ADP/ATP translocator failed to bind mt-CK.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cardiolipin binding  IDA 11565108 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ckmt2  (creatine kinase, mitochondrial 2)


Additional Information