RGD Reference Report - Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schonlein purpura nephritis. - Rat Genome Database

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Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schonlein purpura nephritis.

Authors: Di, B  Li, X  Song, L  Wang, Q  Liu, S 
Citation: Di B, etal., Mol Med Rep. 2012 Nov;6(5):1171-7. doi: 10.3892/mmr.2012.1032. Epub 2012 Aug 10.
RGD ID: 11533935
Pubmed: PMID:22895845   (View Abstract at PubMed)
DOI: DOI:10.3892/mmr.2012.1032   (Journal Full-text)

Previous studies have shown that insertion/deletion polymorphisms in the angiotensin-converting enzyme (ACE) gene and the endothelial nitric oxide synthase (eNOS) gene are associated with Henoch-Schonlein purpura nephritis (HSPN). However, further studies are required to prove the relationship between HSPN and ACE and eNOS single nucleotide polymorphisms (SNPs). We studied six ACE SNPs and two eNOS SNPs by genotyping HSPN patients. Statistical analyses indicate that four ACE SNPs and two eNOS SNPs are associated with HSPN susceptibility. A cumulative effect analysis suggested that an increased number of unfavourable genotypes may lead to an increased risk of HSPN. By comparing alleles, genotypes and haplotypes that are associated with lupus nephritis (LN) and HSPN, we found genetic heterogeneity between HSPN and LN.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nephritis susceptibilityIAGP 11533935associated with Purpura more ...RGD 
nephritis susceptibilityISOACE (Homo sapiens)11533935; 11533935associated with Purpura more ...RGD 
nephritis susceptibilityIAGP 11533935associated with Purpura more ...RGD 
nephritis susceptibilityISONOS3 (Homo sapiens)11533935; 11533935associated with Purpura more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)
NOS3  (nitric oxide synthase 3)

Objects referenced in this article
Gene NOS2 nitric oxide synthase 2 Homo sapiens
Gene Nos2 nitric oxide synthase 2, inducible Mus musculus
Gene Nos2 nitric oxide synthase 2 Rattus norvegicus

Additional Information