RGD Reference Report - Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL).

General

Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL).
Authors:	Demacq, C Vasconcellos, VB Izidoro-Toledo, TC Da Silva Silveira, V Canalle, R Queiroz, RG Tone, LG Tanus-Santos, JE
Citation:	Demacq C, etal., Clin Chim Acta. 2010 Sep 6;411(17-18):1335-40. doi: 10.1016/j.cca.2010.05.025. Epub 2010 May 25.
RGD ID:	11533646
Pubmed:	PMID:20510681 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.cca.2010.05.025 (Journal Full-text)
BACKGROUND: Angiogenesis has been shown as an important process in hematological malignancies. It consists in endothelial proliferation, migration, and tube formation following pro-angiogenic factors releasing, specially the vascular endothelial growth factor (VEGF), which angiogenic effect seems to be dependent on nitric oxide (NO). We examined the association among functional polymorphisms in these two angiogenesis related genes: VEGF (-2578C>A, -1154G>A, and -634G>C) and NOS3 (-786T>C, intron 4 b>a, and Glu298Asp) with prognosis of childhood acute lymphoblastic leukemia (ALL). METHODS: The genotypes were determined and haplotypes estimated in 105 ALL patients that were divided in 2 groups: high risk (HR) and low risk of relapse (LR) patients. In addition, event-free survival curves according to genotypes were assessed. RESULTS: The group HR compared to the LR showed a higher frequency of the alleles -2578C and -634C and the haplotype CGC for VEGF (0.72 vs. 0.51, p<0.008; 0.47 vs. 0.26, p<0.008; and 42.1 vs. 14.5, p<0.006; respectively) and a lower frequency of the haplotype CbGlu (0.4 vs. 8.8,p<0.006), for NOS3. CONCLUSION: Polymorphisms of VEGF and NOS3 genes are associated with high risk of relapse, therefore may have a prognostic impact in childhood ALL.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
acute lymphoblastic leukemia	disease_progression	IAGP		11533646	DNA:polymorphism more ...	RGD
acute lymphoblastic leukemia	disease_progression	ISO	NOS3 (Homo sapiens)	11533646; 11533646	DNA:polymorphism more ...	RGD

Objects Annotated

Genes (Rattus norvegicus)

Nos3 (nitric oxide synthase 3)

Genes (Mus musculus)

Nos3 (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)

NOS3 (nitric oxide synthase 3)

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Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL).