RGD Reference Report - Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population. - Rat Genome Database

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Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population.

Authors: Qin, J  Dai, J  Xu, Z  Chen, D  Qin, J  Shi, D  Teng, H  Jiang, Q 
Citation: Qin J, etal., PLoS One. 2013 Jul 26;8(7):e70033. doi: 10.1371/journal.pone.0070033. Print 2013.
RGD ID: 11533639
Pubmed: PMID:23922896   (View Abstract at PubMed)
PMCID: PMC3724670   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0070033   (Journal Full-text)

Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute lymphoblastic leukemia susceptibilityIAGP 11533639DNA:SNP: :rs3918186(human)RGD 
acute lymphoblastic leukemia susceptibilityISONOS3 (Homo sapiens)11533639; 11533639DNA:SNP: :rs3918186(human)RGD 
Venous Thrombosis susceptibilityIAGP 11533639associated with orthopedic surgery and DNA:SNP::rs1799983(human)RGD 
Venous Thrombosis susceptibilityISONOS3 (Homo sapiens)11533639; 11533639associated with orthopedic surgery and DNA:SNP::rs1799983(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information