RGD Reference Report - [Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research]. - Rat Genome Database

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[Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research].

Authors: Li, W  Li, J  Gu, J 
Citation: Li W, etal., Zhonghua Yi Xue Za Zhi. 1998 Jun;78(6):413-5.
RGD ID: 11352734
Pubmed: PMID:10923500   (View Abstract at PubMed)

OBJECTIVE: To investigate the effect of recombinant human growth hormone(rhGH) on hypoalbuminemia in peritoneal sepsis. METHODS: We observed rhGH on albumin mRNA expression and albumin sythesis in vitro and in vivo with the method of reverse-transcriptional polymerase chain reaction (RT-PCR). RESULTS: rhGH significantly up-regulated albumin mRNA expression in vitro (143 +/- 6 vs 100.4 +/- 2.2, P < 0.01) and in vivo(152 +/- 8 Vs 100 +/- 3, P < 0.01), and obviously alleviated the inhibition of albumin mRNA expression induced by LPS (P < 0.05). In cecal ligation and puncture-induced septic rats, rhGH significantly raised albumin synthesis(20.4 +/- 1.7 Vs 15.5 +/- 2.9 g/L, P < 0.01) and albumin mRNA expression. In patients with peritoneal sepsis, rhGH in combination with total parenteral nutrition markedly increased serum albumin, prealbumin, and transferrin concentration, but no apparent effect was observed in controls. CONCLUSION: rhGH significantly increases albumin mRNA expression and albumin synthesis in peritoneal sepsis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypoalbuminemia treatmentIDA 11352734associated with SepsisRGD 
Hypoalbuminemia treatmentISOGH1 (Homo sapiens)11352734; 11352734associated with SepsisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gh1  (growth hormone 1)

Genes (Mus musculus)
Gh  (growth hormone)

Genes (Homo sapiens)
GH1  (growth hormone 1)


Additional Information