RGD Reference Report - Calcium mobilizing second messengers derived from NAD. - Rat Genome Database

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Calcium mobilizing second messengers derived from NAD.

Authors: Guse, AH 
Citation: Guse AH Biochim Biophys Acta. 2015 Sep;1854(9):1132-7. doi: 10.1016/j.bbapap.2014.12.015. Epub 2014 Dec 19.
RGD ID: 11251700
Pubmed: PMID:25534250   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbapap.2014.12.015   (Journal Full-text)

Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca(2)(+) mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinucleotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca(2)(+) mobilization by these adenine nucleotides and their putative target Ca(2)(+) channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.


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