RGD Reference Report - Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus. - Rat Genome Database

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Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.

Authors: Yeo, H  Kim, HW  Mo, J  Lee, D  Han, S  Hong, S  Koh, MJ  Sun, W  Choi, S  Rhyu, IJ  Kim, H  Lee, HW 
Citation: Yeo H, etal., Neuroscience. 2012 Dec 6;225:35-43. doi: 10.1016/j.neuroscience.2012.08.062. Epub 2012 Sep 7.
RGD ID: 11079184
Pubmed: PMID:22960622   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2012.08.062   (Journal Full-text)

Synaptotagmins are required for Ca(2+)-dependent membrane-trafficking in either neuronal synaptic vesicles or cellular membranes. Previous reports suggested that the synaptotagmin 11 (syt11) gene is involved in the development of schizophrenia based on the genomic analysis of patients. Parkin protein binds to the C2 domains of Syt11 which leads to the polyubiquitination of Syt11. However, where and how Syt11 performs its role in the brain is largely unknown. Here, we report that Syt11 is expressed mainly in the brain. In addition, exogenously expressed Syt11 in HEK293 cells can form higher molecular weight complex via its transmembrane domain. Also, Syt11 is targeted to both dendrite and axon compartments. Immunocytochemistry showed that Syt11 is juxtaposed to postsynaptic markers in both excitatory and inhibitory synapses. Both neuroligin 1 and 2, which are postsynaptic cell adhesion molecules and differentially induce excitatory and inhibitory presynapses, respectively, recruit Syt11 in neuron coculture. Immunogold electron microscopy analysis revealed that Syt11 exists mainly in presynaptic neurotransmitter vesicles and plasma membrane, and rarely in postsynaptic sites. These results suggest that Syt11 may contribute to the regulation of neurotransmitter release in the excitatory and inhibitory presynapses, and postsynapse-targeted membrane trafficking in dendrites.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
dendritic spine located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
excitatory synapse located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
inhibitory synapse located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
postsynapse is_active_inIDA 11079184PMID:22960622SynGO 
postsynaptic density located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
presynapse located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
presynaptic active zone membrane is_active_inIDA 11079184PMID:22960622SynGO 
presynaptic active zone membrane located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
Schaffer collateral - CA1 synapse is_active_inIDA 11079184PMID:22960622SynGO 
synaptic vesicle located_inIDA 11079184PMID:22960622ParkinsonsUK-UCL 
synaptic vesicle membrane is_active_inIDA 11079184PMID:22960622SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Syt11  (synaptotagmin 11)


Additional Information