RGD Reference Report - The three transcobalamins in myeloproliferative disorders and acute leukaemia. - Rat Genome Database

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The three transcobalamins in myeloproliferative disorders and acute leukaemia.

Authors: Zittoun, J  Zittoun, R  Marquet, J  Sultan, C 
Citation: Zittoun J, etal., Br J Haematol. 1975 Nov;31(3):287-98.
RGD ID: 11060122
Pubmed: PMID:1059479   (View Abstract at PubMed)

The unsaturated vitamin B12 binding capacity of whole serum (UBBC) and of the three transcobalamins (TC) has been studied in patients with various haematological diseases including myeloproliferative disorders (MPD) and acute leukaemia. The binding capacity of TC I and TC III was increased in MPD; TC I being particularly high in chronic granulocytic leukaemia (CGL) and TC III especially raised in polycythaemia rubra vera (PRV) and in infectious leucocytosis. The binding capacity of both TC I and TC III correlated with blood neutrophil count and the ratio TC III/TC I was low in CGL and increased in PRV. TC II was increased in acute myelogenous leukaemia, during remission and blast cell crisis of CGL and in refractory anaemia with excess of myeloblasts but not in acute lymphoblastic leukaemia (ALL). TC II correlated inversely with blood neutrophil count. There is an inverse ratio between TC II and TC I at least in myelogenous leukaemia. These abnormalities are discussed in relation to granulocyte kinetics. TC III and TC I reflect probably the total body granulocyte pool and share some biochemical and immunological properties supporting the view that they have a common origin in the more mature stages of the granulocyte cell line while TC II probably originates partly in more primitive granulocytes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute myeloid leukemia  IEP 11060122protein:increased expression::RGD 
acute myeloid leukemia  ISOTCN2 (Homo sapiens)11060122; 11060122protein:increased expression::RGD 
Blast Crisis  IEP 11060122protein:increased expression::RGD 
Blast Crisis  ISOTCN2 (Homo sapiens)11060122; 11060122protein:increased expression::RGD 
Refractory Anemia  IEP 11060122protein:increased expression::RGD 
Refractory Anemia  ISOTCN2 (Homo sapiens)11060122; 11060122protein:increased expression::RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tcn2  (transcobalamin 2)

Genes (Mus musculus)
Tcn2  (transcobalamin 2)

Genes (Homo sapiens)
TCN2  (transcobalamin 2)


Additional Information