RGD Reference Report - The activity of glucose-6-phosphate dehydroxygenase and glutathione enzymes in red blood cells in patients with haemoblastoses. - Rat Genome Database

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The activity of glucose-6-phosphate dehydroxygenase and glutathione enzymes in red blood cells in patients with haemoblastoses.

Authors: Kumerova, A  Silova, A  Lece, A  Petuchov, V 
Citation: Kumerova A, etal., Mater Med Pol. 1995 Jan-Mar;27(1):7-9.
RGD ID: 11059504
Pubmed: PMID:8569275   (View Abstract at PubMed)

The activity of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GSSG-R), glutathione peroxidase (GSH-Px) and MDA levels have been assayed in red blood cells (RBC), obtained from 57 people suffering from haemoblastoses. The activities of G6PD in the RBC in patients with polycythemia vera (PV) and chronic lymphoid leukemia (CML) are significantly higher than those in healthy patients. Changes in the activity of glutathione dependent enzymes GSSG-R and those of GSH-Px in the RBC go in opposite directions: the activity of GSSG-R is significantly enhanced in patients with PV and CML, but the activity of GSH-Px is decreased in all patients suffering from haemoblastoses. The high levels of MDA in the RBC of all patients with haemoblastoses indicate intensification of lipid peroxidation in their RBC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lymphoid leukemia  IEP 11059504protein:increased activity:erythrocyte:RGD 
lymphoid leukemia  ISOGSR (Homo sapiens)11059504; 11059504protein:increased activity:erythrocyte:RGD 
polycythemia vera  IEP 11059504protein:increased activity:erythrocyte:RGD 
polycythemia vera  ISOGSR (Homo sapiens)11059504; 11059504protein:increased activity:erythrocyte:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsr  (glutathione-disulfide reductase)

Genes (Mus musculus)
Gsr  (glutathione reductase)

Genes (Homo sapiens)
GSR  (glutathione-disulfide reductase)


Additional Information