RGD Reference Report - Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells. - Rat Genome Database

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Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells.

Authors: Banerjee, T  Kuypers, FA 
Citation: Banerjee T and Kuypers FA, Br J Haematol. 2004 Feb;124(3):391-402.
RGD ID: 11059503
Pubmed: PMID:14717789   (View Abstract at PubMed)

Due to their role in oxygen transport and the presence of redox active haemoglobin molecules, red blood cells (RBC) generate relatively high levels of reactive oxygen species (ROS). To counteract the potential deleterious effects of ROS, RBCs have a well-integrated network of anti-oxidant mechanisms to combat this oxidative stress. ROS formation is increased in sickle-cell disease (SCD) and our studies in a murine SCD model showed a significant increase in the generation of ROS when compared with normal mice. Our data also indicated that murine sickle RBCs exhibit a significantly increased ATP catabolism, partly due to the increased activity of glucose-6-phosphate dehydrogenase and glutathione reductase to regenerate intracellular glutathione (GSH) levels to neutralize the adverse milieu of oxidative stress. Higher ATP consumption by the murine sickle RBCs, together with the increased ROS formation and impairment of the aminophospholipid translocase or flipase may underlie the exposure of phosphatidylserine on the surface of these cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sickle cell anemia  ISOGsr (Mus musculus)11059503; 11059503protein:increased activity:erythrocyte:RGD 
sickle cell anemia  IEP 11059503protein:increased activity:erythrocyte:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsr  (glutathione-disulfide reductase)

Genes (Mus musculus)
Gsr  (glutathione reductase)

Genes (Homo sapiens)
GSR  (glutathione-disulfide reductase)


Additional Information