RGD Reference Report - HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group. - Rat Genome Database

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HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group.

Authors: Sarafnejad, A  Khosravi, F  Alimoghadam, K  Dianat, S  Ansaripour, B  Moradi, B  Dorkhosh, S  Amirzargar, A 
Citation: Sarafnejad A, etal., Iran J Allergy Asthma Immunol. 2006 Sep;5(3):115-9.
RGD ID: 11041776
Pubmed: PMID:17237562   (View Abstract at PubMed)
DOI: DOI:05.03/ijaai.115119   (Journal Full-text)

Previous studies have demonstrated some significant differences in HLA allele frequencies in leukemic patients and normal subjects. We have analyzed HLA class II alleles and haplotypes in 60 Iranian patients with acute myelogenous leukemia (AML) and 180 unrelated normal subjects. Blood samples were collected after obtaining informed consents. From the patients and control DNA extraction and HLA typing were performed using PCR-SSP method. Significant positive association with the disease was found for HLA-DRB1*11 allele (35% vs. 24.7%, p=0.033). Two alleles including HLA-DRB4 and -DQB1*0303 were found to be significantly decreased in patients compared to controls. Regarding haplotype analysis, no significant association was found between case and control groups. It is suggested that HLA-DRB1*11 allele plays as a presumptive predisposing factor while the HLA-DRB4 and -DQB1*0303 alleles are suggested as protective genetic factors against acute myelogenous leukemia. Larger studies are needed to confirm and establish the role of these associations with acute myelogenous leukemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute myeloid leukemia  ISOHLA-DQB1 (Homo sapiens)11041776; 11041776 RGD 
acute myeloid leukemia  IAGP 11041776 RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Bb  (RT1 class II, locus Bb)

Genes (Mus musculus)
H2-Ab1  (histocompatibility 2, class II antigen A, beta 1)

Genes (Homo sapiens)
HLA-DQB1  (major histocompatibility complex, class II, DQ beta 1)


Additional Information