RGD Reference Report - Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage. - Rat Genome Database

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Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage.

Authors: Gargano, JW  Holzman, CB  Senagore, PK  Reuss, ML  Pathak, DR  Friderici, KH  Jernigan, K  Fisher, R 
Citation: Gargano JW, etal., Am J Obstet Gynecol. 2009 Sep;201(3):317.e1-9. doi: 10.1016/j.ajog.2009.05.060.
RGD ID: 11039046
Pubmed: PMID:19733287   (View Abstract at PubMed)
PMCID: PMC3018335   (View Article at PubMed Central)
DOI: DOI:10.1016/j.ajog.2009.05.060   (Journal Full-text)

OBJECTIVE: The purpose of this study was to analyze functional polymorphisms in candidate genes (methylenetetrahydrofolate reductase [MTHFR]677C>T, MTHFR1298A>C, factor 5 1691G>A [FVL], and angiotensinogen (AGT)-6G>A) in relation to a hypothesized placental hemorrhage pathway to preterm delivery (PTD). STUDY DESIGN: We assessed maternal genotypes, pregnancy outcomes, and placental pathologic evidence among 560 white and 399 black women who were recruited at mid trimester into a prospective cohort study (1998-2004). Odds of dominant genotypes were calculated for PTDs with (n = 56) or without (n = 177) evidence of placental hemorrhage (referent = term) with the use of race-stratified polytomous logistic regression models. RESULTS: Among white women, FVL GA/AA and AGT(-6) GA/AA were both associated with hemorrhage-related PTDs (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.6-14.2 and OR, 3.8; 95% CI, 1.3-10.5, respectively), but not other PTDs (ORs, 1.2 and 0.9, respectively). FVL GA/AA was associated with placental abruption (OR, 5.8; 95% CI, 1.1-30) among white women. All results were null for MTHFR genotypes. CONCLUSION: FVL and AGT variant genotypes were associated specifically with hemorrhage-related PTDs.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hemorrhage  IAGP 11039046associated with Premature Birth and DNA:polymorphism:promoter:-6G>A (human)RGD 
Hemorrhage  ISOAGT (Homo sapiens)11039046; 11039046associated with Premature Birth and DNA:polymorphism:promoter:-6G>A (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agt  (angiotensinogen)

Genes (Mus musculus)
Agt  (angiotensinogen)

Genes (Homo sapiens)
AGT  (angiotensinogen)


Additional Information