RGD Reference Report - Beneficial effects of beta-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats. - Rat Genome Database

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Beneficial effects of beta-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats.

Authors: Yang, HY  Wu, LY  Yeh, WJ  Chen, JR 
Citation: Yang HY, etal., Br J Nutr. 2014 Jan 14;111(1):78-85. doi: 10.1017/S0007114513001876. Epub 2013 Jun 27.
RGD ID: 11039044
Pubmed: PMID:23803175   (View Abstract at PubMed)
DOI: DOI:10.1017/S0007114513001876   (Journal Full-text)

The objective of the present study was to investigate the effects of beta-conglycinin and soya isoflavones on diabetic nephropathy (DN). DN was induced by an intravenous injection of streptozotocin (25 mg/kg) in spontaneously hypertensive rats. DN rats were divided into a non-diabetic group (C, control group) and three DN groups (D, DN with control diet; B, DN+control diet with one-eighth of casein replaced by beta-conglycinin as the protein source; and I, DN+control diet with 0.01 % soya isoflavones). After a 4-week experimental period, we found that fasting blood sugar and plasma and kidney advanced glycation end product levels and 24 h urinary protein excretion of the B group were significantly lower than those of the D group and insulin sensitivity and nephrin expression of the B group were significantly higher than those of the D group. In addition, systolic blood pressure, angiotensin-converting enzyme activity, angiotensin II level and plasma TAG level of the B group were significantly lower than those of the D group, whereas only the levels of plasma TAG and thiobarbituric acid-reactive substances of the I group were lower than those of the D group. In conclusion, beta-conglycinin may be beneficial for retarding DN progression and this effect cannot be completely explained by its isoflavone content.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies treatmentISOAce (Rattus norvegicus)11039044; 11039044associated with Diabetes Mellitus and ExperimentalRGD 
Diabetic Nephropathies treatmentIDA 11039044associated with Diabetes Mellitus and ExperimentalRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information