RGD Reference Report - Serum albumin level as a risk factor for mortality in burn patients. - Rat Genome Database

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Serum albumin level as a risk factor for mortality in burn patients.

Authors: Aguayo-Becerra, OA  Torres-Garibay, C  Macias-Amezcua, MD  Fuentes-Orozco, C  Chavez-Tostado Mde, G  Andalon-Duenas, E  Espinosa Partida, A  Alvarez-Villasenor Adel, S  Cortes-Flores, AO  Gonzalez-Ojeda, A 
Citation: Aguayo-Becerra OA, etal., Clinics (Sao Paulo). 2013 Jul;68(7):940-5. doi: 10.6061/clinics/2013(07)09.
RGD ID: 11036092
Pubmed: PMID:23917657   (View Abstract at PubMed)
PMCID: PMC3714858   (View Article at PubMed Central)
DOI: DOI:10.6061/clinics/2013(07)09   (Journal Full-text)

OBJECTIVE: Hypoalbuminemia is a common clinical deficiency in burn patients and is associated with complications related to increased extravascular fluid, including edema, abnormal healing, and susceptibility to sepsis. Some prognostic scales do not include biochemical parameters, whereas others consider them together with comorbidities. The purpose of this study was to determine whether serum albumin can predict mortality in burn patients. METHODS: We studied burn patients >/=16 years of age who had complete clinical documentation, including the Abbreviated Burn Severity Index, serum albumin, globulin, and lipids. Sensitivity and specificity analyses were performed to determine the cut-off level of albumin that predicts mortality. RESULTS: In our analysis of 486 patients, we found that mortality was higher for burns caused by flame (p=0.000), full-thickness burns (p=0.004), inhalation injuries (p=0.000), burns affecting >30% of the body surface area (p=0.001), and burns associated with infection (p=0.008). Protein and lipid levels were lower in the patients who died (p<0.05). Albumin levels showed the highest sensitivity and specificity (84% and 83%, respectively), and the area under the receiver-operating characteristic curve (0.869) had a cut-off of 1.95 g/dL for mortality. CONCLUSION: Patients with albumin levels <2 g/dL had a mortality risk of >80%, with 84% sensitivity and 83% specificity. At admission, the albumin level could be used as a sensitive and specific marker of burn severity and an indicator of mortality.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Burns disease_progressionIEP 11036092 RGD 
Burns disease_progressionISOALB (Homo sapiens)11036092; 11036092 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alb  (albumin)

Genes (Mus musculus)
Alb  (albumin)

Genes (Homo sapiens)
ALB  (albumin)


Additional Information