RGD Reference Report - Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India. - Rat Genome Database

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Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India.

Authors: Poonkuzhali, B  Shaji, RV  Salamun, DE  George, B  Srivastava, A  Chandy, M 
Citation: Poonkuzhali B, etal., Acta Haematol. 2005;114(3):127-32.
RGD ID: 10450878
Pubmed: PMID:16227674   (View Abstract at PubMed)
DOI: DOI:10.1159/000087885   (Journal Full-text)

The etiology of acquired aplastic anemia (AA) in most patients remains unclear. It is believed that patients with a reduced ability to detoxify environmental toxins are at increased risk of developing AA. Cytochrome P450 (CYP450) and glutathione S transferase (GST) are the major phase I and phase II xenobiotic-metabolizing enzymes. We analyzed the impact of the polymorphisms in CYP4501A1 and GSTM1 and GSTT1 genes on the susceptibility and disease severity in 200 patients with AA and compared the frequency with the normal population. There was a significantly increased frequency of the CYP1A1m4 allele in AA patients compared with normal controls (odds ratio = 3.01; 95% confidence interval 1.76-5.17; p = 0.00001). None of the other CYP1A1 genotypes or the GST genotypes were significantly different between AA patients and controls. Altered metabolism of benzo(a)pyrene due to the polymorphism in the CYP1A1 gene might be an etiologic factor in the increased incidence of AA in these patients. The CYP1A1m4 allele may play a role in determining the risk of AA in India.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
aplastic anemia no_associationIAGP 10450878 RGD 
aplastic anemia no_associationISOGSTT1 (Homo sapiens)10450878; 10450878 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTT1  (glutathione S-transferase theta 1)


Additional Information