RGD Reference Report - [The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants]. - Rat Genome Database

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[The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants].

Authors: Lvova, O A  Gusev, V V  Kuznetsov, N N  Baranov, D A  Voroshilina, E S  Partylova, E A 
Citation: Lvova OA, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9 Pt 2):13-20.
RGD ID: 10450767
Pubmed: PMID:24107890   (View Abstract at PubMed)

The data on the risk factors and etiology of ischemic stroke in 31 infants, aged under 3 years, are summarized. The results of genotyping of blood coagulation and folic acid gene polymorphisms in patients and 83 healthy people are presented. Significant differences were found for -455 G>A FGB (¿=0.03) and 807 C>T ITGA2 (¿=0,005) polymorphisms. Different gene-gene combinations that can cause hypercoagulation and arterial thrombosis in this age were identified. The most frequent combinations include polymorphisms of genes for FGB, fibrinolysis system and folate cycle enzymes (OR=3,79 and more, p<0.05). A clinical case of ischemic stroke in a girl, aged 10 months, after operated congenital heart malformation is presented.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Stroke susceptibilityIAGP 10450767DNA:polymorphism: :-455G>A(human)RGD 
Stroke susceptibilityISOFGB (Homo sapiens)10450767; 10450767DNA:polymorphism: :-455G>A(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fgb  (fibrinogen beta chain)

Genes (Mus musculus)
Fgb  (fibrinogen beta chain)

Genes (Homo sapiens)
FGB  (fibrinogen beta chain)


Additional Information