RGD Reference Report - Developmental expression of mRNAs from a rat C-erbA genomic locus. - Rat Genome Database

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Developmental expression of mRNAs from a rat C-erbA genomic locus.

Authors: Jannini, EA  Mitsuhashi, T  Nikodem, VM 
Citation: Jannini EA, etal., Biochem Biophys Res Commun. 1992 Apr 30;184(2):739-45.
RGD ID: 10448989
Pubmed: PMID:1315530   (View Abstract at PubMed)

The thyroid hormone receptor alpha gene is alternatively spliced to give the alpha receptor and a variant which does not bind thyroid hormones. An additional alpha-like receptor (Rev-erbA alpha) is transcribed on the opposite strand and overlaps the unique variant sequence. The alpha receptor in rat brain reaches peak levels 5-15 days after birth. The variant remains high from 2 days before birth to old age. The Rev-erbA alpha mRNA increases beginning 5 days after birth, maximizing in adulthood. Thyroid hormone decreases and hypothyroidism increases the level of these 3 messages. We conclude that the levels of these messages are similarly controlled by thyroid hormone but have different ontogenetic controls. No functional results can be seen in vivo from potential anti sense pairing of Rev-erbA alpha with the variant.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Nr1d1  (nuclear receptor subfamily 1, group D, member 1)

Genes (Mus musculus)
Nr1d1  (nuclear receptor subfamily 1, group D, member 1)

Genes (Homo sapiens)
NR1D1  (nuclear receptor subfamily 1 group D member 1)


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