RGD Reference Report - Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease. - Rat Genome Database

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Nerve growth factor receptor expressing human basal forebrain neurons: pathologic alterations in Alzheimer's and Parkinson's disease.

Authors: Mufson, EJ  Kordower, JH 
Citation: Mufson EJ and Kordower JH, Prog Clin Biol Res. 1989;317:401-14.
RGD ID: 10414073
Pubmed: PMID:2557638   (View Abstract at PubMed)

Normal aged human basal forebrain tissue immunohistochemically stained with a monoclonal antibody for nerve growth factor receptor (NGFR) revealed a continuum of NGFR containing neurons in brain regions corresponding to Ch1-Ch4. NGFR immunoreactive neurons were observed within the medial septum (Ch1), vertical (Ch2) and horizontal (Ch3) limb nuclei of the diagonal band and nucleus basalis (Ch4) complex. Occasional dystrophic NGFR containing neurons were observed within the Ch subfields. Colocalization experiments demonstrated that virtually all (95%) NGFR containing perikarya stained positively for the specific cholinergic marker acetylcholinesterase. On the other hand, occasional cholinergic negative NGFR positive neurons were seen in the putamen of the striatal complex. In Alzheimer's disease, subfields of the basal forebrain revealed extensive neuronal loss and shrinkage, dystrophic fibers as well as normal appearing neurons. Each AD case exhibited an individual pattern of cell loss. Within the Ch1-4 subfields NGFR and ChAT colocalized, indicating that the NGFR remained coupled to cholinergic neurons in AD. In some Parkinson's cases there was a severe loss of NGFR containing basal forebrain neurons. These findings indicate that NGFR containing basal forebrain neurons colocalize with ChAT, are severely affected in AD, in some PD cases, and NGFR remains coupled to cholinergic perikarya in both neurodegenerative disorders.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 10414073 RGD 
Alzheimer's disease  ISONGFR (Homo sapiens)10414073; 10414073 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)


Additional Information