RGD Reference Report - Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease. - Rat Genome Database

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Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease.

Authors: Perry, EK  Irving, D  Kerwin, JM  McKeith, IG  Thompson, P  Collerton, D  Fairbairn, AF  Ince, PG  Morris, CM  Cheng, AV 
Citation: Perry EK, etal., Alzheimer Dis Assoc Disord. 1993 Summer;7(2):69-79.
RGD ID: 10413896
Pubmed: PMID:8347330   (View Abstract at PubMed)

Senile dementia of Lewy body type or Lewy body dementia (LBD), characterized neuropathologically by the presence of Lewy bodies in the brainstem and cortex, and in most cases neocortical senile plaques (but few or no tangles), bears a closer resemblance to Parkinson's (PD) than to Alzheimer disease (AD) in its cholinergic neurochemical pathology. Thus, reductions in the biochemical activity of choline acetyltransferase were generally more extensive in neo- as opposed to archicortical regions in LBD (especially hallucinating cases) and in PD, whereas muscarinic receptor binding was significantly increased in LBD and PD but not in AD. Nerve growth factor receptor (P75) assessed immunocytochemically in the archicortex were decreased in PD and, to a lesser extent, in LBD in conjunction with reductions of neuronal numbers in the nucleus of Meynert (Ch4), but were relatively spared in AD. These observations indicate that although AD is primarily associated with dysfunction of cholinergic axonal input to the cortex, LBD and PD are more likely to involve degeneration of the basal forebrain cholinergic system. Relevance of the findings in terms of aetiopathology and cholinergic treatment strategies is discussed.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lewy body dementia  IEP 10413896protein:decreased expression:brainRGD 
Lewy body dementia  ISONGFR (Homo sapiens)10413896; 10413896protein:decreased expression:brainRGD 
Parkinson's disease  IEP 10413896protein:decreased expression:brainRGD 
Parkinson's disease  ISONGFR (Homo sapiens)10413896; 10413896protein:decreased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)


Additional Information