RGD Reference Report - Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease. - Rat Genome Database

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Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease.

Authors: Lindner, MD  Gordon, DD  Miller, JM  Tariot, PN  McDaniel, KD  Hamill, RW  DiStefano, PS  Loy, R 
Citation: Lindner MD, etal., Arch Neurol. 1993 Oct;50(10):1054-60.
RGD ID: 10413893
Pubmed: PMID:8215963   (View Abstract at PubMed)

OBJECTIVE: In Alzheimer's disease, cholinergic basal forebrain neurons, which have receptors for nerve growth factor (NGF), degenerate, while NGF receptors increase in some areas of the neocortex. Levels of the truncated, extracellular portion of the NGF receptor (NGF-Rt) are elevated in urine of patients with peripheral neuropathies and in animals with peripheral-nerve injury, but it has not been determined whether urine levels of NGF-Rt are altered by the presence and/or progression of dementia-related neuropathologic changes in patients with Alzheimer's disease. In this study, we developed an enzyme-linked immunosorbent assay to determine whether urine levels of NGF-Rt are altered in patients with Alzheimer's disease. DESIGN: Survey of urine NGF-Rt levels in neurologically normal (n = 19), mildly demented (n = 31), and moderately to severely demented (n = 31) patients. SETTING: Subjects were participants in the Rochester Alzheimer's Disease Project and mildly demented patients about to begin a clinical drug study. PATIENTS: All patients met established criteria for a clinical diagnosis of probable Alzheimer's disease. Aged, nondemented, neurologically normal controls were selected from the families of the demented subjects. RESULTS: Urine NGF-Rt levels were substantially elevated in mildly demented patients relative to those of nondemented controls. CONCLUSIONS: These results suggest that an enzyme-linked immunosorbent assay on urine samples may provide an antemortem measure of dementia-related neuropathologic changes, but further study is needed to determine the source and potential clinical utility of increased NGF-Rt levels in urine of mildly demented patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 10413893protein:altered expression:urineRGD 
Alzheimer's disease  ISONGFR (Homo sapiens)10413893; 10413893protein:altered expression:urineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngfr  (nerve growth factor receptor)

Genes (Mus musculus)
Ngfr  (nerve growth factor receptor (TNFR superfamily, member 16))

Genes (Homo sapiens)
NGFR  (nerve growth factor receptor)


Additional Information