RGD Reference Report - Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma.

General

Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma.
Authors:	Sood, R Ritov, G Richter-Levin, G Barki-Harrington, L
Citation:	Sood R, etal., Behav Brain Res. 2013 Mar 1;240:26-8. doi: 10.1016/j.bbr.2012.11.009. Epub 2012 Nov 20.
RGD ID:	10412309
Pubmed:	PMID:23174211 (View Abstract at PubMed)
DOI:	DOI:10.1016/j.bbr.2012.11.009 (Journal Full-text)
Chronic infusion of mice with a beta2 adrenergic receptor (beta2AR) analog was shown to cause long-term DNA damage in a pathway which involves beta Arresin-1-mediated activation of Mdm2 and subsequent degradation of the tumor suppressor protein p53. The objective of the present study was to test whether a single acute stress, which manifests long lasting changes in behavior, affects the interaction of Mdm2 with p53, beta2AR, and beta Arrestin-1 in the dorsal and ventral hippocampal CA1. Adult rats were subject to underwater trauma, a brief forceful submersion under water and tested a month later for behavioral and biochemical changes. Elevated plus maze tests confirmed that animals that experienced the threat of drowning present heightened levels of anxiety one month after trauma. An examination of the CA1 hippocampal areas of the same rats showed that underwater trauma caused a significant increase in the association of Mdm2 with beta2AR, beta Arrestin-1, and p53 in the ventral but not dorsal CA1. Our results provide support for the idea that stress-related events may result in biochemical changes restricted to the ventral 'emotion-related' parts of the hippocampus.

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
post-traumatic stress disorder		ISO	Mdm2 (Rattus norvegicus)	10412309; 10412309		RGD
post-traumatic stress disorder		IDA		10412309		RGD

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
response to water-immersion restraint stress		IDA		10412309		RGD

Objects Annotated

Genes (Rattus norvegicus)

Mdm2 (MDM2 proto-oncogene)

Genes (Mus musculus)

Mdm2 (transformed mouse 3T3 cell double minute 2)

Genes (Homo sapiens)

MDM2 (MDM2 proto-oncogene)

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Selective increase in the association of the beta2 adrenergic receptor, beta Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma.