RGD Reference Report - LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. - Rat Genome Database

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LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia.

Authors: Pandey, P  Pradhan, S  Mittal, B 
Citation: Pandey P, etal., Genes Brain Behav. 2008 Nov;7(8):943-50. doi: 10.1111/j.1601-183X.2008.00436.x. Epub 2008 Aug 21.
RGD ID: 10412053
Pubmed: PMID:18721259   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1601-183X.2008.00436.x   (Journal Full-text)

Difference in genetic makeup of lipid metabolizing proteins may increase susceptibility to dementia. The aim of this study was to investigate variations in two lipid metabolizing genes, low-density lipoprotein receptor-related protein-associated protein gene (LRPAP) and apolipoprotein E (APOE), in vascular and degenerative dementias. This hospital-based association study included 147 patients with dementia and 163 age-matched controls. Genotyping for LRPAP1 intron 5 insertion/deletion and APOEHhaI polymorphism was carried out by polymerase chain reaction (PCR)/PCR-restriction fragment length polymorphism method. The frequency of DD genotype and *D allele of LRPAP gene was high in degenerative dementias compared with controls (76.6% vs. 44.8% and 86.4% vs. 69.3%, respectively) suggesting increased susceptibility [P < 0.0001, odds ratio (OR) =3.76 for DD genotype and P < 0.0001, OR = 2.80 for D allele]. Vascular dementia patients showed statistically insignificant but increasing trend for allele I (40.0% vs. 30.7%). We also observed significant association of APOEepsilon4 allele with degenerative dementias (P < 0.0001, OR =5.35). Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dementia susceptibilityIAGP 10412053DNA:insertion and deletion:intron:RGD 
dementia susceptibilityISOLRPAP1 (Homo sapiens)10412053; 10412053DNA:insertion and deletion:intron:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lrpap1  (LDL receptor related protein associated protein 1)

Genes (Mus musculus)
Lrpap1  (low density lipoprotein receptor-related protein associated protein 1)

Genes (Homo sapiens)
LRPAP1  (LDL receptor related protein associated protein 1)


Additional Information