RGD Reference Report - Polymorphisms and vascular cognitive impairment after ischemic stroke. - Rat Genome Database

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Polymorphisms and vascular cognitive impairment after ischemic stroke.

Authors: Baum, L  Chen, X  Cheung, WS  Cheung, CK  Cheung, LW  Chiu, KF  Wen, HM  Poon, P  Woo, KS  Ng, HK  Wong, KS 
Citation: Baum L, etal., J Geriatr Psychiatry Neurol. 2007 Jun;20(2):93-9.
RGD ID: 10402374
Pubmed: PMID:17548779   (View Abstract at PubMed)
DOI: DOI:10.1177/0891988706298627   (Journal Full-text)

Environmental and genetic factors may both affect the risk of vascular cognitive impairment developing after a stroke. To identify factors affecting this risk, the cognitive status of 121 patients was examined 3 months after an ischemic stroke. In all patients and in 270 control subjects, 7 polymorphisms reported to affect risk of vascular ischemic disease were genotyped. In 51 patients (42.1%), vascular cognitive impairment resulted, defined by a Mini-Mental State Examination score of less than 24. These patients were older and more likely to be women. Alleles of none of the polymorphisms differed between patients with or without vascular cognitive impairment, except for glutamate-cysteine ligase modifier (GCLM) (odds ratio = 2.8, P = .006). When all stroke patients were considered, the GCLM genotype did not affect Mini-Mental State Examination scores. Testing the GCLM genotype in an independent group of stroke patients may determine whether this association with vascular cognitive impairment is genuine.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
vascular dementia susceptibilityIAGP 10402374associated with stroke and DNA:polymorphism:promoter:-588C>T(human)RGD 
vascular dementia susceptibilityISOGCLM (Homo sapiens)10402374; 10402374associated with stroke and DNA:polymorphism:promoter:-588C>T(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gclm  (glutamate cysteine ligase, modifier subunit)

Genes (Mus musculus)
Gclm  (glutamate-cysteine ligase, modifier subunit)

Genes (Homo sapiens)
GCLM  (glutamate-cysteine ligase modifier subunit)


Additional Information