RGD Reference Report - Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. - Rat Genome Database

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Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome.

Authors: Shim, KS  Lubec, G 
Citation: Shim KS and Lubec G, Neurosci Lett. 2002 May 24;324(3):209-12.
RGD ID: 10398822
Pubmed: PMID:12009525   (View Abstract at PubMed)

Drebrin, located in the dendritic spines of the neuron, plays a role in the synaptic plasticity together with actin filaments. Although drebrin regulates the morphological changes of spines in neurodegenerative disease such as Alzheimer's disease (AD), drebrin in Down syndrome (DS) showing AD-like neuropathology has not been studied. We used Western blotting to determine protein levels of drebrin and F-actin in frontal, temporal cortex and cerebellum from patients with DS and AD as compared to controls. A monoclonal antibody against drebrin and F-actin was used. Drebrin levels were significantly decreased in frontal (means +/- standard deviation; DS 0.24 +/- 0.52; AD 0.16 +/- 0.14; controls 2.56 +/- 3.48) and temporal cortex (DS 0.07 +/- 0.11; AD 0.07 +/- 0.15; controls 1.71 +/- 1.51) and drebrin was also decreased when normalized with F-actin. No changes were observed in cerebellum. Decreased drebrin could not simply be due to cell loss (F-actin) or neuronal loss (comparable neuron-specific enolase between groups). Reduced drebrin could be responsible for or representing the loss of spine plasticity in DS and may be a useful indicator for the impaired arborization in neurodegenerative disorders.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Down syndrome  IEP 10398822protein:decreased expression:frontal cortex and temporal cortex:RGD 
Down syndrome  ISODBN1 (Homo sapiens)10398822; 10398822protein:decreased expression:frontal cortex and temporal cortex:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dbn1  (drebrin 1)

Genes (Mus musculus)
Dbn1  (drebrin 1)

Genes (Homo sapiens)
DBN1  (drebrin 1)


Additional Information