RGD Reference Report - The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury. - Rat Genome Database

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The terminal pathway of the complement system is activated in focal penetrating but not in mild diffuse traumatic brain injury.

Authors: Rostami, E  Davidsson, J  Gyorgy, A  Agoston, DV  Risling, M  Bellander, BM 
Citation: Rostami E, etal., J Neurotrauma. 2013 Dec 1;30(23):1954-65. doi: 10.1089/neu.2012.2583. Epub 2013 Oct 30.
RGD ID: 10054313
Pubmed: PMID:23808389   (View Abstract at PubMed)
DOI: DOI:10.1089/neu.2012.2583   (Journal Full-text)

The complement system plays an important role in the inflammatory response activated by many central nervous system disorders. However, its significance in traumatic diffuse traumatic axonal injury (TAI) is not fully known. Here we analyze the complement activity in two rat models of traumatic brain injury (TBI); a focal penetration injury (pen-TBI) and a rotational acceleration injury (rot-TBI) that leads to a mild TAI. We used in situ hybridization to examine the distribution of mRNA for C1q and C3 and immunohistochemistry to examine the presence of the C3 protein and C5b-9 complex at 1-5 days after injury. We found a time-dependent complement activity in both models. However, the responses caused by the two models were different. We detected C5b-9 surrounding the cavity in pen-TBI, but C5b-9 was not found in the rot-TBI. Our findings suggest that the terminal complement pathway is progressed to the formation of the C5b-9 membrane attack complex only in the penetrating TBI but not in isolated TAI model. This indicates that the complement activation does not lead to membrane-damaging effects and a subsequent secondary axotomy in TAI by the terminal complex C5b-9. The role of complement activation in TAI is unclear, but might indicate an alternative function following rot-TBI, such as opsonizing the synapses for elimination.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOC1qa (Rattus norvegicus)10054313; 10054313 RGD 
Brain Injuries  IEP 10054313; 10054313 RGD 
Brain Injuries  ISOC3 (Rattus norvegicus)10054313; 10054313 RGD 

Objects Annotated

Genes (Rattus norvegicus)
C1qa  (complement C1q A chain)
C3  (complement C3)

Genes (Mus musculus)
C1qa  (complement component 1, q subcomponent, alpha polypeptide)
C3  (complement component 3)

Genes (Homo sapiens)
C1QA  (complement C1q A chain)
C3  (complement C3)


Additional Information