RGD Reference Report - Altered cell-matrix associated ADAM proteins in Alzheimer disease. - Rat Genome Database

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Altered cell-matrix associated ADAM proteins in Alzheimer disease.

Authors: Gerst, JL  Raina, AK  Pirim, I  McShea, A  Harris, PL  Siedlak, SL  Takeda, A  Petersen, RB  Smith, MA 
Citation: Gerst JL, etal., J Neurosci Res. 2000 Mar 1;59(5):680-4.
RGD ID: 10047127
Pubmed: PMID:10686596   (View Abstract at PubMed)
DOI: DOI:10.1002/(SICI)1097-4547(20000301)59:5<680::AID-JNR11>3.0.CO;2-6   (Journal Full-text)

Alterations in cell-matrix 'contact' are often related to a disruption of cell cycle regulation and, as such, occur variously in neoplasia. Given the recent findings showing cell cycle alterations in Alzheimer disease, we undertook a study of ADAM-1 and 2 (A Disintegrin And Metalloprotease), developmentally-regulated, integrin-binding, membrane-bound metalloproteases. Our results show that whereas ADAM-1 and 2 are found in susceptible hippocampal neurons in Alzheimer disease, these proteins were not generally increased in similar neuronal populations in younger or age-matched controls except in association with age-related neurofibrillary alterations. This increase in both ADAM-1 and 2 in cases of Alzheimer disease was verified by immunoblot analysis (P < 0.05). An ADAM-induced loss of matrix integration would effectively "reset" the mitotic clock and thereby stimulate re-entry into the cell cycle in neurons in Alzheimer disease. Furthermore, given the importance of integrins in maintaining short-term memory, alterations in ADAM proteins or their proteolytic activity could also play a proximal role in the clinico-pathological manifestations of Alzheimer disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 10047127protein:increased expression:brainRGD 
Alzheimer's disease  ISOADAM2 (Homo sapiens)10047127; 10047127protein:increased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adam2  (ADAM metallopeptidase domain 2)

Genes (Mus musculus)
Adam2  (a disintegrin and metallopeptidase domain 2)

Genes (Homo sapiens)
ADAM2  (ADAM metallopeptidase domain 2)


Additional Information