RGD Reference Report - GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine. - Rat Genome Database

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GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine.

Authors: Gerasimov, MR  Schiffer, WK  Gardner, EL  Marsteller, DA  Lennon, IC  Taylor, SJ  Brodie, JD  Ashby CR, JR  Dewey, SL 
Citation: Gerasimov MR, etal., Eur J Pharmacol. 2001 Mar 2;414(2-3):205-9.
RGD ID: 10047061
Pubmed: PMID:11239920   (View Abstract at PubMed)

Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously paired with cocaine administration. In animals exposed to a cocaine-paired environment nucleus accumbens dopamine increased by 25%. When administered 2.5 h prior to presentation of the environmental trigger, racemic vigabatrin (an irreversible inhibitor of gamma-aminobutyric acid (GABA)-transaminase) abolished this cue-induced increase. Conversely, R-(-)-vigabatrin, the inactive enantiomer, had no effect. Combined with our earlier findings, these studies support the potential therapeutic benefit of this enzyme-based GABAergic strategy to modulate brain dopamine and the subsequent treatment of drug addiction.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of dopamine metabolic process  IMP 10047061 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abat  (4-aminobutyrate aminotransferase)


Additional Information