RGD Reference Report - Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele. - Rat Genome Database

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Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele.

Authors: Murphy GM, JR  Claassen, JD  DeVoss, JJ  Pascoe, N  Taylor, J  Tinklenberg, JR  Yesavage, JA 
Citation: Murphy GM Jr, etal., Neurology. 2001 Jun 12;56(11):1595-7.
RGD ID: 10045947
Pubmed: PMID:11402127   (View Abstract at PubMed)

The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 alpha (IL-1 alpha) -889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1 alpha -889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no difference in rate of decline between patients with and without the APOE epsilon 4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease disease_progressionIAGP 10045947DNA:SNP:5'UTR:rs1800587(human)RGD 
Alzheimer's disease disease_progressionISOIL1A (Homo sapiens)10045947; 10045947DNA:SNP:5'UTR:rs1800587(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)


Additional Information